Chronic Inflammation or Diseases
- Sclerosing cholangitis (inflammation of the bile duct)
- Ulcerative colitis (inflammation of the large intestine)
- Bile duct stones
- Gallbladder stones
- Pancreatitis
- Irritable bowel syndrome
Chronic inflammation or irritation may also develop into diseases or conditions that are associated with bile duct cancer.
Inherited Causes of Bile Duct Cancer
There are a few rare inherited disorders, like Caroli disease (also called Caroli's syndrome), that may make some people more prone to infection, thereby increasing irritation of the bile ducts and the risk of cancer. However, most cases of bile duct cancer do not appear to a have a familial link.
Age
Bile duct cancer is not very common in young or middle-aged adults. Over 60 percent of bile duct cancer patients are 65 or older.
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